منابع مشابه
Epigenetics and pharmacology.
Recent advances in the understanding of gene regulation have shown there to be much more regulation of the genome than first thought, through epigenetic mechanisms. These epigenetic mechanisms are systems that have evolved to either switch off gene activity altogether, or fine-tune any existing genetic activation. Such systems are present in all genes and include chromatin modifications and rem...
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Chan KY, Labruijere S, de Vries R, Danser AHJ, Villalón CM, MaassenVanDen Brink A. Cranioselectivity of sumatriptan revisited. J. Headache Pain, 2010 oct; 11 Suppl.1):203 Labruijere S, Chan KY, van Houten ELAF, de Vries R, Kramer P, Danser AHJ, Villalón CM, Visser JA, MaassenVanDen Brink A. The effect of DHT on vascular reactivity. J. Headache Pain, 2010 oct; 11 Suppl.1):201 Labruijere S, Chan ...
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Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...
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Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...
متن کاملEpigenetics
By the time the reader reaches Chapter 20, which focuses specifically on cancer, the mechanisms and symptoms of cancer are relatively easy to understand. Chapter 20 covers topics such as the cellular phenotypes of cancer, genes linked to cancer, and cancer treatment. While the primary literature citations at the end of the chapter will provide good starting points for the curious student, a mor...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2015
ISSN: 0007-1188
DOI: 10.1111/bph.13136